School of Applied Physiology, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Extensive documentation exists showing that exercise induces analgesia and sedation. Despite decades of research attempting to explicate a neurochemical basis for these phenomena, the mechanism underlying these changes is unknown. Using trained male college students running on a treadmill or cycling on a stationary bike for 50 min at 70-80% of maximum heart rate, we report here the first evidence that exercise of moderate intensity activates the endocannabinoid system, suggesting a new mechanism for exercise-induced analgesia and possibly other physiological and psychological adaptations to exercise.
- [PubMed – indexed for MEDLINE]
- Analysis of Variance
- Arachidonic Acids/blood*
- Cannabinoid Receptor Modulators/blood*
- Exercise Test/methods
- Polyunsaturated Alkamides