Elucidating opportunities and pitfalls in the treatment of experimental traumatic brain injury to optimize and facilitate clinical translation.

Neurosci Biobehav Rev. 2017 May 30. pii: S0149-7634(17)30088-X. doi: 10.1016/j.neubiorev.2017.05.022.

[Epub ahead of print]

de la Tremblaye PB¹, O’Neil DA¹, LaPorte MJ¹, Cheng JP¹, Beitchman JA², Thomas TC³, Bondi CO⁴, Kline AE⁵.

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Abstract

The aim of this review is to discuss the research presented in a symposium entitled “Current progress in characterizing therapeutic strategies and challenges in experimental CNS injury” which was presented at the 2016 International Behavioral Neuroscience Society annual meeting. Herein we discuss diffuse and focal traumatic brain injury (TBI) and ensuing chronic behavioral deficits as well as potential rehabilitative approaches. We also discuss the effects of stress on executive function after TBI as well as the response of the endocrine system and regulatory feedback mechanisms. The role of the endocannabinoids after CNS injury is also discussed. Finally, we conclude with a discussion of antipsychotic and antiepileptic drugs, which are provided to control TBI-induced agitation and seizures, respectively. The review consists predominantly of published data.

KEYWORDS:

Morris water maze (MWM); antiepileptic drugs (AEDs); antipsychotic drugs (APDs); controlled cortical impact (CCI); endocannabinoids; executive function; fluid percussion (FP) injury; rehabilitation; stress; traumatic brain injury

PMID: 28576511

DOI: 10.1016/j.neubiorev.2017.05.022