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Anticancer mechanisms of cannabinoids.

  Journal List > Curr Oncol > v.23(Suppl 2); 2016 Mar > PMC4791144 Curr Oncol. 2016 Mar; 23(Suppl 2): S23–S32.  Published online 2016 Mar 16. doi:  10.3747/co.23.3080 PMCID: PMC4791144 Anticancer mechanisms of cannabinoids G. Velasco, PhD,*†‡ C. Sánchez, PhD,*§ and  M. Guzmán, PhD*†‖ Author information ► Copyright and License information ► Go to: Abstract In addition to the well-known palliative effects of cannabinoids on some cancer-associated symptoms, a large body […]

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Marijuana’s Influence on Pain Scores, Initial Weight Loss, and Other Bariatric Surgical Outcomes.

Perm J. 2018 Jul 19;22. doi: 10.7812/TPP/18-002. Bauer FL1, Donahoo WT2, Hollis HW Jr3, Tsai AG4, Pottorf BJ5, Johnson JM6, Silveira LJ7, Husain FA8. Author information Abstract INTRODUCTION: Pain management can be challenging following bariatric surgery, and patients with obesity tend to increase opioid use after undergoing surgery. This report quantifies marijuana (MJ) use and […]

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Integrating endocannabinoid signaling in the regulation of anxiety and depression.

Acta Pharmacol Sin. 2018 Jul 12. doi: 10.1038/s41401-018-0051-5. [Epub ahead of print] Yin AQ1, Wang F2, Zhang X1,3. Author information Abstract Brain endogenous cannabinoid (eCB) signaling seems to harmonize appropriate behavioral responses, which are essential for the organism’s long-term viability and homeostasis. Dysregulation of eCB signaling contributes to negative emotional states and increased stress responses. […]

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The Pharmacokinetics and the Pharmacodynamics of Cannabinoids.

Br J Clin Pharmacol. 2018 Jul 12. doi: 10.1111/bcp.13710. [Epub ahead of print] Lucas CJ1,2,3, Galettis P1,2,4, Schneider J1,2,3,5. Author information Abstract There is increasing interest in the use of cannabinoids for disease and symptom management, but limited information available regarding their pharmacokinetics and pharmacodynamics to guide prescribers. Cannabis medicines contain a wide variety of […]

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Long-term safety and treatment effects of cannabidiol in children and adults with treatment-resistant epilepsies: Expanded access program results.

Epilepsia. 2018 Jul 12. doi: 10.1111/epi.14477. [Epub ahead of print] Szaflarski JP1, Bebin EM1, Comi AM2, Patel AD3, Joshi C4, Checketts D5, Beal JC6, Laux LC7, De Boer LM8, Wong MH9, Lopez M10, Devinsky O11, Lyons PD12, Zentil PP10, Wechsler R13; CBD EAP study group. Collaborators (9) Author information Abstract OBJECTIVE: Since 2014, cannabidiol (CBD) […]

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Effectiveness of Raw, Natural Medical Cannabis Flower for Treating Insomnia under Naturalistic Conditions.

Medicines (Basel). 2018 Jul 11;5(3). pii: E75. doi: 10.3390/medicines5030075. Vigil JM1, Stith SS2, Diviant JP3, Brockelman F4, Keeling K5, Hall B6. Author information Abstract Background: We use a mobile software application (app) to measure for the first time, which fundamental characteristics of raw, natural medical Cannabis flower are associated with changes in perceived insomnia under […]

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Marijuana use and short-term outcomes in patients hospitalized for acute myocardial infarction.

PLoS One. 2018 Jul 11;13(7):e0199705. doi: 10.1371/journal.pone.0199705. eCollection 2018. Johnson-Sasso CP1, Tompkins C1, Kao DP1, Walker LA1. Author information Abstract Marijuana use is increasing worldwide, and it is ever more likely that patients presenting with acute myocardial infarctions (AMI) will be marijuana users. However, little is known about the impact of marijuana use on short-term […]

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Behind Schedule — Reconciling Federal and State Marijuana Policy

The long-standing chasm between federal and state marijuana policy recently widened when U.S. Attorney General Jeff Sessions rescinded Obama-era guidance indicating that the Justice Department would not make it a priority to prosecute federal marijuana crimes in states where the activities are legal. At present, a budgetary amendment is the only legal barrier to Justice […]

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Medical Cannabis Legalization and Opioid Prescriptions: Evidence on US Medicaid Enrollees during 1993-2014.

Addiction. 2018 Jul 10. doi: 10.1111/add.14382. [Epub ahead of print] Liang D1, Bao Y2, Wallace M3, Grant I4, Shi Y1. Author information Abstract BACKGROUND AND AIMS: While the US has been experiencing an opioid epidemic, 29 states and Washington DC have legalized cannabis for medical use. This study examined whether statewide medical cannabis legalization was […]

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Open-label use of Highly* purified CBD (Epidiolex®) in patients with CDKL5 deficiency disorder and Aicardi, Dup15q, and Doose syndromes.

Epilepsy Behav. 2018 Jul 10. pii: S1525-5050(18)30191-4. doi: 10.1016/j.yebeh.2018.05.013. [Epub ahead of print] Devinsky O1, Verducci C2, Thiele EA3, Laux LC4, Patel AD5, Filloux F6, Szaflarski JP7, Wilfong A8, Clark GD9, Park YD10, Seltzer LE11, Bebin EM12, Flamini R13, Wechsler RT14, Friedman D15. Author information Abstract OBJECTIVE: We studied our collective open-label, compassionate use experience […]