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Biorefining of industrial hemp (Cannabis sativa L.) threshing residues into cannabinoid and antioxidant fractions by supercritical carbon dioxide, pressurized liquid and enzyme-assisted extractions.

Food Chem. 2018 Nov 30;267:420-429. doi: 10.1016/j.foodchem.2017.09.080. Epub 2017 Sep 18. Kitrytė V1, Bagdonaitė D1, Rimantas Venskutonis P2. Author information Abstract C. sativa threshing residues were biorefined by consecutive supercritical carbon dioxide (SFE-CO2) pressurised liquid (PLE) and enzyme-assisted extractions (EAE). SFE-CO2 at optimised parameters yielded 8.3g/100g of lipophilic fraction containing 0.2 and 2.2g of cannabidiol […]

Behavioral symptoms in premanifest Huntington disease correlate with reduced frontal CB1R levels.

J Nucl Med. 2018 Jun 22. pii: jnumed.118.210393. doi: 10.2967/jnumed.118.210393. [Epub ahead of print] Ceccarini J1, Ahmad R2, Van de Vliet L3, Casteels C4, Vandenbulcke M3, Vandenberghe W1, Van Laere K5. Author information Abstract Many Huntington disease (HD) mutation carriers already have cognitive and psychiatric symptoms in the premanifest (premotor) phase of the disease, but […]

Pain Modulation after Oromucosal Cannabinoid Spray (SATIVEX®) in Patients with Multiple Sclerosis: A Study with Quantitative Sensory Testing and Laser-Evoked Potentials.

Medicines (Basel). 2018 Jun 21;5(3). pii: E59. doi: 10.3390/medicines5030059. Turri M1, Teatini F2, Donato F3, Zanette G4, Tugnoli V5, Deotto L6, Bonetti B7, Squintani G8. Author information Abstract Background. Delta-9-tetrahydrocannabinol (THC)/cannabidiol (CBD) (nabiximols or Sativex®) is an oromucosal spray formulation containing THC and CBD at an approximately 1:1 fixed ratio. Its administration for the treatment […]

Medicinal Cannabinoids in Palliative Care.

Br J Clin Pharmacol. 2018 Jun 20. doi: 10.1111/bcp.13671. [Epub ahead of print] Agar M1,2,3. Author information Abstract The treatment of symptoms in people with palliative diagnoses begins with meticulous clinical assessment with treatment choice (s) selected based on an understanding of the symptom aetiology and the evidence which underpins its treatment. Increasingly the merits […]

The challenges of ‘medical cannabis’ and mental health: a clinical perspective.

Br J Clin Pharmacol. 2018 Jun 20. doi: 10.1111/bcp.13687. [Epub ahead of print] Newton-Howes G1. Author information Abstract The use of cannabis as a medicine has a long tradition in western medicine. It has been seen as a viable option for the treatment of various neurological and psychiatric conditions, and recently there is again interest […]

Driving Under the Influence of Cannabis: A Framework for Future Policy.

Anesth Analg. 2018 Jun 20. doi: 10.1213/ANE.0000000000003575. [Epub ahead of print] Chow RM1, Marascalchi B2, Abrams WB3, Peiris NA4, Odonkor CA3, Cohen SP5,6. Author information Abstract Marijuana is the most widely consumed illicit substance in the United States, and an increasing number of states have legalized it for both medicinal and recreational purposes. As it […]

Endocrine disruptors in the diet of male Sparus aurata: Modulation of the endocannabinoid system at the hepatic and central level by Di-isononyl phthalate and Bisphenol A.

Environ Int. 2018 Jun 19;119:54-65. doi: 10.1016/j.envint.2018.06.011. [Epub ahead of print] Forner-Piquer I1, Mylonas CC2, Calduch-Giner J3, Maradonna F1, Gioacchini G1, Allarà M4, Piscitelli F4, Di Marzo V4, Pérez-Sánchez J3, Carnevali O5. Author information Abstract The increasing manufacture of plastics and their mismanagement has turned plastic into a ubiquitous waste in the marine environment. Among […]

Cannabinoid receptor types 1 and 2 and peroxisome proliferator-activated receptor-α: distribution in the skin of clinically healthy cats and cats with hypersensitivity dermatitis.

Vet Dermatol. 2018 Jun 19. doi: 10.1111/vde.12658. [Epub ahead of print] Miragliotta V1, Ricci PL1, Albanese F2, Pirone A1, Tognotti D3, Abramo F1. Author information Abstract BACKGROUND: Cannabinoid receptors and peroxisome proliferator-activated receptor-alpha (PPAR-α) are gaining recognition as potential therapeutic targets for the treatment of skin disorders. HYPOTHESIS/OBJECTIVES: The aim of this study was to […]

Cannabis, cannabis everywhere: UK to review medical cannabis policy as Canada plans imminent legalisation for all uses

Feature War on Drugs BMJ 2018; 361 doi: (Published 19 June 2018)Cite this as: BMJ 2018;361:k2695 Editorial Cannabis as medicine Opinion Medical cannabis: it is time to provide legal access, the UK must not get left behind Article Related c Richard Hurley, features editor, The BMJ As the UK government weathers sustained criticism […]

Positron emission tomography of type 2 cannabinoid receptors for detecting inflammation in the central nervous system

Review Article | Published: 19 June 2018 Ruiqing Ni, Linjing Mu & Simon Ametamey Acta Pharmacologica Sinica (2018) | Download Citation Cannabinoid receptor CB2 (CB2R) is upregulated on activated microglia and astrocytes in the brain under inflammatory conditions and plays important roles in many neurological diseases, such as Alzheimer’s disease, amyotrophic lateral sclerosis, and ischemic […]