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PM 2 site 207

Acute inflammation: endogenous cannabinoids mellow the harsh proinflammatory environment.

J Clin Invest. 2018 Aug 13. pii: 122885. doi: 10.1172/JCI122885. [Epub ahead of print] Neish AS. Abstract Under normal conditions, there is a paucity of neutrophils within the intestinal mucosa; however, these innate immune cells rapidly infiltrate the mucosa in response to infection and are critical for pathogen control. Unfortunately, these cells can cause extensive […]

PM 2 site 207

Cannabidiol for treating drug-resistant epilepsy in children: the New South Wales experience.

Med J Aust. 2018 Aug 13. [Epub ahead of print] Chen KA1, Farrar M2, Cardamone M2, Gill D3, Smith R4, Cowell CT5, Truong L6, Lawson JA2. Author information Abstract OBJECTIVE: To evaluate the tolerability and safety of cannabidiol for treating drug-resistant epilepsy in children, and to describe adverse events associated with such treatment. STUDY DESIGN: […]

PM 2 site 207

Medicinal cannabis in Australia, 2016: the Cannabis as Medicine Survey (CAMS-16).

Med J Aust. 2018 Aug 13. [Epub ahead of print] Lintzeris N1, Driels J2, Elias N3, Arnold JC4, McGregor IS4, Allsop DJ3. Author information Abstract OBJECTIVE: To explore patterns of cannabis use for medical purposes in Australia immediately prior to the 2016 legislation for frameworks for medical cannabis use.Design, setting: Anonymous online survey with convenience […]

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Effects of cannabidiol, a Cannabis sativa constituent, on oral wound healing process in rats: Clinical and histological evaluation.

Phytother Res. 2018 Aug 8. doi: 10.1002/ptr.6165. [Epub ahead of print] Klein M1, de Quadros De Bortolli J1, Guimarães FS2, Salum FG1, Cherubini K1, de Figueiredo MAZ1. Author information Abstract The effects of cannabidiol (CBD), the main non-psychotropic component of Cannabis sativa, were assessed on oral wound healing in an in vivo model. Standardized ulcers […]

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Treatment of Periodontal Ligament Stem Cells with MOR and CBD Promotes Cell Survival and Neuronal Differentiation via the PI3K/Akt/mTOR Pathway.

Int J Mol Sci. 2018 Aug 9;19(8). pii: E2341. doi: 10.3390/ijms19082341. Lanza Cariccio V1, Scionti D2, Raffa A3, Iori R4, Pollastro F5, Diomede F6, Bramanti P7, Trubiani O8, Mazzon E9. Author information Abstract Periodontal ligament mesenchymal stem cells (hPDLSCs), as well as all mesenchymal stem cells, show self-renewal, clonogenicity, and multi-tissue differentiation proprieties and can […]

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Cannabinoid-1 Receptor Regulates Mitochondrial Dynamics and Function in Renal Proximal Tubular Cells.

Diabetes Obes Metab. 2018 Aug 9. doi: 10.1111/dom.13497. [Epub ahead of print] Drori A1, Permyakova A1, Hadar R1, Udi S1, Nemirovski A1, Tam J1. Author information Abstract AIMS: To evaluate the specific role of the endocannabinoid/CB1 R system in modulating mitochondrial dynamics in the metabolically active renal proximal tubular cells (RPTCs). MATERIALS AND METHODS: We […]

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Cannabidiol improves frequency and severity of seizures and reduces adverse events in an open-label add-on prospective study.

Epilepsy Behav. 2018 Aug 9. pii: S1525-5050(18)30473-6. doi: 10.1016/j.yebeh.2018.07.020. [Epub ahead of print] Szaflarski JP1, Bebin EM2, Cutter G3, DeWolfe J2, Dure LS4, Gaston TE2, Kankirawatana P4, Liu Y3, Singh R4, Standaert DG5, Thomas AE2, Ver Hoef LW2; UAB CBD Program. Author information Abstract The objective of this study was to characterize the changes in […]

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The Role of Cannabis within an Emerging Perspective on Schizophrenia.

Medicines (Basel). 2018 Aug 8;5(3). pii: E86. doi: 10.3390/medicines5030086. Diviant JP1, Vigil JM2, Stith SS3. Author information Abstract Background: Approximately 0.5% of the population is diagnosed with some form of schizophrenia, under the prevailing view that the pathology is best treated using pharmaceutical medications that act on monoamine receptors. Methods: We briefly review evidence on […]

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Glial Endocannabinoid System in Pain Modulation.

Int J Neurosci. 2018 Aug 7:1-12. doi: 10.1080/00207454.2018.1503178. [Epub ahead of print] Wang J1. Author information Abstract Pain is affecting the human for centuries and there still is no satisfactory strategy for patients suffering pain particularly chronic pain although intensive studies about its mechanism have been performed in order to improve the treatment of pain. […]

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Neuronal preservation and reactive gliosis attenuation following neonatal sciatic nerve axotomy by a fluorinated cannabidiol derivative.

Neuropharmacology. 2018 Aug 7. pii: S0028-3908(18)30483-0. doi: 10.1016/j.neuropharm.2018.08.009. [Epub ahead of print] Perez M1, Cartarozzi LP1, Chiarotto GB1, Alves de Oliveira S1, Guimarães FS2, Rodrigues de Oliveira AL3. Author information Abstract Immature peripheral nervous system damage, such as the transection of a peripheral nerve, results in the extensive degeneration of motoneurons and dorsal root ganglia […]