Graphical abstract

Illustration of metabolic relationships between 2-acyl LPA, 2-acyl LPI and 2-AG and their cognate receptors. The lipid ligands can interconvert and interact with GPR35, GPR55 and cannabinoid receptors.

 

Keywords

  • G-protein coupled receptor;
  • Cannabinoid;
  • GPR35;
  • GPR55;
  • Lysophospholipid

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Fig. 1. Structures of ligands and related compounds. The three endogenous ligands, 2-arachidonyl LPA (2-acyl LPA), 2-arachidonyl LPI (2-acyl LPA) and 2-arachidonyl glycerol (2-AG) for GPR35, GPR55 and cannabinoid receptors are structurally related. Kynurenic acid is another GPR35 endogenous agonist. Kynurenine and tryptophan are two compounds related to kynurenic acid.
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Fig. 2. Illustration of metabolic relationships between 2-acyl LPA, 2-acyl LPI and 2-AG and their cognate receptors. The lipid ligands can interconvert and interact with GPR35, GPR55 and cannabinoid receptors.
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