Marijuana, Inc. supports the Medical Marijuana industry and The Cash Hyde Foundation
—>*47 kids are diagnosed with cancer each day and 7 kids will die. Only 3% of all money raised for cancer research goes to pediatric cancer. In 2010 Cashy recieved Chemotherapy developed in 1976 and in 2011 Cashy recieved Radiation developed in the early part of 1980. Cancer is a multi Billion dollar industry annually and kills nearly 1,800 each day. Americas Terrorist is cancer and the individuals who dictate to us what medicines and foods we can consume.<—
DadGivesCannabis OiltoToddlerBattlingBrain Cancer– Medical Marijuana
To call what the Hyde family has been through a “parent’s worst nightmare” sounds like a horrible cliche. But, it’s hard to imagine what else you could call it. At the tender age of 2 years old, their son Cash was diagnosed with a stage 4 brain tumor; he nearly died more times than they can count. He was miserable from the chemotherapy coursing through his body. Until his dad made a controversial decision to give cannabis to his young son.
What They Do,
The Cash Hyde Foundation:
The fact is, in one way or another, cancer may affect us all. That’s why it is up to all of us to play a part in fighting cancer during our lifetime. Cashy’s journey has given us all the opportunity to unite, with the same common goal, help children fighting cancer.
Their Mission
The Cash Hyde Foundation’s mission is to fight cancer with smiles, prayers, positive energy and provide information and financial support for children with cancer and their families.
Fighting Cancer with Smiles
Most kids are transported around the hospital in little tyke’s rubber wagons and cars. It is awesome to see how happy it makes the kids to get out of their rooms and have a little fun. We learned that you can fight Cancer one smile at a time and that even if the smile only lasts a minute it is a minute that Cancer isn’t winning. Unfortunately the wagons/cars are limited also it is hard to maneuver them and the IV poles without two people and tangling the IV lines.
Reggae Runners
We decided one day that the wagons and cars needed to be customized with stickers and have IV poles mounted to them. We purchased Cashy his own Little Tike’s car and mounted a Reggae Colored IV pole to it. We put stickers of Bob Marley One Love, Monkey’s, Cancer Fears Me, 4th ICS, and our favorite hometown team, the University of Montana Grizzlies all over it. We named it the Reggae Runner and Cashy had many happy times cruising the halls of Primary Children’s in it.
How They Help
• Make custom Reggae Runners, and donate them to patients at Children’s Hospitals.
• Help families in need organize fundraisers so they can concentrate on fighting cancer.
• Collect donations and organize fundraiser’s to financially assist the foundation with its projects and financial support for children with cancer and their families.
• Create childhood cancer awareness in our communities and support for children with cancer and their families.
This video conveys the a basic knowledge of he endocannabinoid system inside the human body.
” In the late 1980s scientists would discover the Endocannabinoid System within the Human body, now this would lay waste to claims for decades that cannabinoids had no beneficial purpose for human consumption.”–William Martin
Cannabis Science
Prof. Robert Melamede – Holistic Biochemistry of Cannabinoids -01-
Dr. Melamede, Associate Professor and Biology Chairman, Biology Department, University of Colorado, explains how the Endocannabinoid System functions as a “Global Homeostatic Regulator”, balancing several organ systems. He theorizes that, “Free Radicals are the Friction of Life. Endocannabinoids are the Oil of Life.”
On this video filmed in 2006, Dr. Robert Melamede, Professor of Biology at the University of Colorado, explains how the body’s Endo-Cannabinoid system (and plant based Cannabinoids as suppliment) kills cancer cells and inhibits tumor growth.
Refering to 1974 U.S.government-sponsored study when THC was found to slow growth of cancer cells
Refering to “Homeostatic Regulation” of several body systems by Cannabinoids, Dr. Melamede concludes that Cannabis is indeed a “Miracle Drug”, also recommending hemp oil as excellent source of EFAs the body needs to fight disease.
Dr. Guzman will be at the 2008 Cannabis Therapeutics Conference this April. More info:
The following presentation of RUN FROM THE CURE: The Rick Simpson Story was made possible by Rick Simpson and video producer Christian Laurette… made for free to teach YOU how to heal yourself of disease and illness using cannabinoids.http://www.phoenixtears.ca
Spiral Up With Ava Marie – Part 1 – Dennis Hill, Biochemist cures his cancer with cannabinoid oil.
Rick Simpson and Christian Laurette have “given” you the recipe to cure yourself…. free of charge. Hemp oil (cannabinoid oil) is not sold in stores, that is “Hemp seed oil” and it is good for you but it won’t cure diseases or help with pain. Hemp oil IS cannabinoids extracted from the buds of the female marijuana/hemp plant. You have to get buds or this will not be potent enough to cure serious disease; this has been proven… take my word on it or take your chances with your doctor. RUN FROM THE CURE: The Rick Simpson Story, a film by Christian Laurette Available for free athttp://www.youtube.com/chrychek
RUN FROM THE CURE: The Rick Simpson Story… “IF YOU SEE ONLY ONE DOCUMENTARY THIS YEAR… MAKE IT THIS ONE!” “THIS MOVIE SAVED MY LIFE!” “I CURED MY CANCER WITH CANNABIS OIL! http://www.phoenixtears.ca
Spiral Up With Ava Marie – Part 2 – Dennis Hill, Biochemist cures his cancer with cannabinoid oil.
Cancer-specific Cytotoxicity of Cannabinoids
By: Dennis Hill
First let’s look at what keeps cancer cells alive, then we will come back and examine how the cannabinoids CBD (cannabidiol) and THC (tetrahydrocannabinol) unravels cancer’s aliveness.
In every cell there is a family of interconvertible sphingolipids that specifically manage the life and death of that cell. This profile of factors is called the “Sphingolipid Rheostat.” If ceramide (a signaling metabolite of sphingosine-1- phosphate) is high, then cell death (apoptosis) is imminent. If ceramide is low, the cell will be strong in its vitality.
Very simply, when THC connects to the CB1 or CB2 cannabinoid receptor site on the cancer cell, it causes an increase in ceramide synthesis which drives cell death. A normal healthy cell does not produce ceramide in the presence of THC, thus is not affected by the cannabinoid.
The cancer cell dies, not because of cytotoxic chemicals, but because of a tiny little shift in the mitochondria. Within most cells there is a cell nucleus, numerous mitochondria (hundreds to thousands), and various other organelles in the cytoplasm. the purpose of the mitochondria is to produce energy (ATP) for cell use. As ceramide starts to accumulate, turning up the Sphingolipid Rheostat, it increases the mitochondrial membrane pore permeability to cytochrome c, a critical protein in energy synthesis. Cytochrome c is pushed out of the mitochondria, killing the source of energy for the cell.
Ceramide also causes genotoxic stress in the cancer cell nucleus generating a protein called p53, whose job it is to disrupt calcium metabolism in the mitochondria. If this weren’t enough, ceramide disrupts the cellular lysosome, the cell’s digestive system that provides nutrients for all cell functions. Ceramide, and other sphingolipids, actively inhibit pro-survival pathways in the cell leaving no possibility at all of cancer cell survival.
The key to this process is the accumulation of ceramide in the system. This means taking therapeutic amounts of cannabinoid extract, steadily, over a period of time, keeping metabolic pressure on this cancer cell death pathway.
How did this pathway come to be? Why is it that the body can take a simple plant enzyme and use it for healing in many different physiological systems? This endocannabinoid system exists in all animal life, just waiting for it’s matched exocannabinoid activator.
This is interesting. Our own endocannabinoid system covers all cells and nerves; it is the messenger of information flowing between our immune system andthe central nervous system (CNS). It is responsible for neuroprotection, and micro- manages the immune system. This is the primary control system that maintains homeostasis; our well being.
Just out of curiosity, how does the work get done at the cellular level, and where does the body make the endocannabinoids? Here we see that endocannabinoids have their origin in nerve cells right at the synapse. When the body is compromised through illness or injury it calls insistently to the endocannabinoid system and directs the immune system to bring healing. If these homeostatic systems are weakened, it should be no surprise that exocannabinoids perform the same function. It helps the body in the most natural way possible.
To see how this works we visualize the cannabinoid as a three dimensional molecule, where one part of the molecule is configured to fit the nerve or immune cell receptor site just like a key in a lock. There are at least two types of cannabinoid receptor sites, CB1 (CNS) and CB2 (immune). In general CB1 activates the CNS messaging system, and CB2 activates the immune system, but it’s much more complex than this. Both THC and anandamide activate both receptor sites. Other cannabinoids activate one or the other receptor sites. Among the strains of Cannabis, C. sativa tends toward the CB1 receptor, and C. indica tends toward CB2. So sativa is more neuroactive, and indica is more immunoactive. Another factor here is that sativa is dominated by THC cannabinoids, and indica is predominately CBD (cannabidiol).
It is known that THC and CBD are biomimetic to anandamide, that is, the body can use both interchangeably. Thus, when stress, injury, or illness demand more from endogenous anandamide than can be produced by the body, its mimetic exocannabinoids are activated. If the stress is transitory, then the treatment can be transitory. If the demand is sustained, such as in cancer, then treatment needs to provide sustained pressure of the modulating agent on the homeostatic systems.
Typically CBD gravitates to the densely packed CB2 receptors in the spleen, home to the body’s immune system. From there, immune cells seek out and destroy cancer cells. Interestingly, it has been shown that THC and CBD cannabinoids have the ability to kill cancer cells directly without going through immune intermediaries. THC and CBD hijack the lipoxygenase pathway to directly inhibit tumor growth. As a side note, it has been discovered that CBD inhibits anandamide reuptake. Here we see that cannabidiol helps the body preserve its own natural endocannabinoid by inhibiting the enzyme that breaks down anandamide.
This brief survey touches lightly on a few essential concepts. Mostly I would like to leave you with an appreciation that nature has designed the perfect medicine that fits exactly with our own immune system of receptors and signaling metabolites to provide rapid and complete immune response for systemic integrity and metabolic homeostasis.
Sami Sarfaraz, Farrukh Afaq, Vaqar M. Adhami, and Hasan Mukhtar + Author Affiliations. Department of Dermatology, University of Wisconsin, Madison, Wisconsin
J Neuroimmunol. 2007 Mar;184(1-2):127-35. Epub 2006 Dec 28. Immune control by endocannabinoids – new mechanisms of neuroprotection? Ullrich O, Merker K, Timm J, Tauber S. Institute of Immunology, Medical Faculty, Otto-von-Guericke-University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany. oliver.ullrich@medizine.uni-magdeburg.de
Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb. Angelo A. Izzo, Francesca Borrelli, Raffaele Capasso, Vincenzo Di Marzo, and Raphael Mechoulam. Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy. Institute of Biomolecular Chemistry, National Research Council, Pozzuoli (NA), Italy. Department of Medicinal Chemistry and Natural Products, Hebrew University Medical Faculty, Jerusalem, Israel, Endocannabinoid Research Group, Italy
NIH Public Access: A house divided: ceramide, sphingosine, and sphingosine-1-phosphate in programmed cell death Tarek A. Taha, Thomas D. Mullen, and Lina M. Obeid Division of General Internal Medicine, Ralph H. Johnson Veterans Administration Hospital, Charleston, South Carolina 29401; and Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425 Corresponding author: Lina M. Obeid, M.D., Department of Medicine, Medical University of South Carolina, 114 Doughty St., P.O.Box 250779, Charleston, South Carolina 29425. E-mail: obeidl@musc.edu
Cannabis Oil Cured My Skin Cancer
When his cancer came back for a fifth time, Michael McShane was desperate for treatment outside of traditional medicine.
The last time squamous cell carcinoma left lumpy tumors around his mouth, doctors cut it away and reconstructed his bottom lip by turning out a portion of its inner layer.
“You can only do most facial tricks once,” McShane, 51, said. “I needed another option.” As a qualifying medical marijuana patient, he tried “Simpson oil” derived from cannabis plants by a Canadian named Rick Simpson. McShane bought some from an Oak Park dispensary that has since closed and puts a few drops every day on his face. Over the course of about 10 weeks, the tumors faded and then seemed to disappear. His dermatologist, Ali Moiin, M.D., has said McShane isn’t cured but his cancer cells have decreased by about 60 percent. “You still have some residual ones, but the size has definitely decreased,” Dr. Moiin told a WWJ reporter in late August, adding he thinks the results merit further scientific study. Moiin didn’t return phone calls for an interview for this story. He isn’t the doctor who signed the physician certification form for McShane’s marijuana user card. McShane has another qualifying medical problem. In all, since the Michigan Medical Marijuana Program started in April 2009, 2,215 of the state’s licensed physicians have certified a patient as eligible for a user card. The certification means that the patient suffers from one of the debilitating conditions identified in the act, and that the patient may find therapeutic and palliative relief from the medical use of marijuana. A total of 105,458 patient registry cards have been issued in that time period. An estimated 55 doctors signed 70 percent of the certification forms, according to one review; most of the others aren’t talking about it publicly. “I imagine it is a fairly sensitive issue because it is politically charged,” said Colin Ford, director of state and federal government relations for the Michigan State Medical Society. Physicians are cautious because patient privacy is important, he said.
Forbidden cure?
Privacy isn’t as important to McShane as sharing what he considers his latest triumph over cancer without surgery, radiation, chemotherapy, reconstructive surgery and their side effects. “The marijuana oil replaced all that and reduced the cancer to almost nothing,” he said. “My forehead and mouth were in bad shape in the spring. All of a sudden one morning it was there — a callous-like growth the size of a half dollar on my forehead. Skin cancer is my regular nemesis.” McShane is one of a growing number of people extolling the healing properties of Simpson oil for everything from cancer, AIDS, Crohn’s disease, osteoporosis, arthritis, and diabetes to psoriasis, hemorrhoids and warts. They call it a “forbidden cure,” saying the oil that can be used topically or ingested isn’t given enough credit because it would cut into medical and pharmaceutical profits. “I’ve struggled with cancer for over 20 years and probably have spent over $1 million on conventional treatment,” McShane said, adding he was insured until his payments increased to $1,400 a month. “I can’t believe what just wiping Simpson oil on my skin did for me. I spent a couple hundred dollars versus $100,000.”
Qualifying conditions
McShane is one of 3,119 patients certified in the state through Aug. 31 for using medical marijuana to treat cancer and its side effects. “Severe and chronic pain is the most common box checked as a medical condition,” said Celeste Clarkson, manager of the Michigan Medical Marijuana Program, which is administered through the Department of Licensing and Regulatory Affairs. The number of medical marijuana patients certified by doctors for severe and chronic pain totaled 99,304 through the end of August, when the latest figures were tallied. The second most common box checked is muscle spasms for 31,779 registered patients, followed by severe nausea for 13,617 patients and then cancer for 3,119 patients. In all, the state act defines 14 chronic or debilitating diseases, medical conditions, and side effects from treatments that qualify, including glaucoma, HIV/AIDS, hepatitis C, amyotrophic lateral sclerosis, Chrohn’s disease, agitation of Alzheimer’s disease, nail patella, Cachexia or wasting syndrome, and seizures. The MMP has 21,000 applications pending. The staff was increased from three at the onset to 25 employees. They have 15 days to approve or deny an application and then five calendar days to issue the medical marijuana card. It is taking months for patients to get their cards. “We’re inundated,” Clarkson said. “The volume of applications is constant. We average 400-600 a day. We’ve received as many as just shy of 2,000 in one day. That was in March. Right now we’re issuing registration cards for new applications received in May.”
‘Now this is a mom’
Christiana Offerman, 36, of Sterling Heights, is certified to use medical marijuana for severe and chronic pain. Fifteen years ago she was diagnosed with fibromyalgia, a disorder that causes widespread muscle and bone pain, fatigue and sleep and mood problems. Offerman had been taking prescriptions of Vicodin as needed for pain, almost the highest dosage allowed of Neurontin for burning and stabbing pain, muscle relaxers, sleeping pills, and Ativan for the anxiety and depression caused by the stress of living with a painful incurable disorder. The side effects of painkillers and muscle relaxers made it tough for the working mom to meet the needs of her two teenage children and respite care clients. “I was lethargic and in bed, unable to respond,” Offerman said. “I was unbalanced, uncoordinated and very groggy. I wasn’t part of my kids’ lives.” After she became a registered medical marijuana patient in late 2009, Offerman said she started using topical cannabis oil for nerve pains in her arm and burning pains in her back. She also smokes marijuana for “all-over body relief.” She said she has stopped taking five prescriptions, including Vicodin, Neurontin, Ativan and sleeping pills. “It was relieving, liberating,” Offerman said. “I make dinner at dinner time. I go to school conferences, football games and dances. I’ve gotten to know my kids better. They are so happy. Now this is a mom.”
New attitudes
Offerman started outing herself as a medical marijuana patient in spring 2010 to educate the public. “At first I didn’t tell people because I was ashamed,” she said. “My son is in marching band. I work for a health agency. There was a stigma, but contrary to popular opinions, we’re not all tie-dyed hippies who want to get high all day. We’re doctors, lawyers, moms and dads.” Offerman said when people find out she uses medical marijuana they are curious and ask a lot of questions. Her employer has no problem with it. “In their eyes, it’s not a drug; it’s a medical option,” she said. “As long as I have a card on file, it’s good with them. I have told my primary care physician, too. She couldn’t sign my paper work because she’s affiliated with a medical group, but she knows what prescription drugs I don’t need anymore and that I don’t get my blood drawn every six months anymore.” Offerman and McShane said they are trying to change attitudes about medical marijuana one person at a time. “I want to make it socially acceptable, something that warrants respect,” McShane said. “It’s here for a reason. God made it and we can turn it into something absolutely beautiful.” Now that the dispensary where he got Simpson oil has closed, McShane is learning how to make it himself. He said he is a “conservative” caregiver for himself and four patients, keeping three plants in various growth stages so he can harvest some marijuana every couple weeks. A caregiver can grow up to 12 plants for a qualifying patient and can assist up to five patients. “I play by the rules,” McShane said. “I’m the caregiver model and I’m curing cancer on the side.”
Cured: A Cannabis Story – David Triplett ^^^ Translations available ^^^
Cured Too A Cancer Story A Film By David Triplett
“This is a documentary of how myself and others cured our cancers using an alternative and controversial treatment: cannabis oil. It’s a proven fact that CBD and THC, two of many components in cannabis, shrink tumors and cure cancer. This documentary shows my cancer being cured and explores the history and politics of cannabis and cancer. You will also see samples of many antique cannabis medicine bottles.”~ Kuro Groves
1974 study, from Medical College of Virginia: http://www.ukcia.org/research/AntineoplasticActivityOfCannabinoids/index.php (2000) http://americanmarijuana.org/Guzman-Cancer.pdf
DISCLAIMER: this video is for information purposes only and is not medical advice. Do go see your doctor if you have concerns about your health, but be sure to make informed decisions about your care.
Brave Mykayla on NBC4LA about Cannabis Oil and its healing effects on cancer
Cannabinoid Oil made from the buds of the Cannabis plant enduce Programmed Cell Death.
Cannabinoid Oil known as Cannabis Oil and many others, cures disease such as cancer, indeed it does. People will always claim, argue, complain, deny that ingesting- meaning eating orally- Cannabis Oil will not cure because they have not/ will not allow room in their brain for new information, new truth.
Most assume we mean smoking Cannabis cures disease or they don’t understand what processes are triggered by ingesting Cannabis Oil, ones that promote cancer cell death… to these people we say research more, and stop letting ignorance ruin your ways of belief. People are dying because some still believe this is a joke, hoax or myth, that’s incredibly sad. Share this video and visit our facebook page:
www.facebook.com/CannabinoidsCureDisease
usually 1 LB of cannabis BUDS, not stems/roots or leaves. try to have ALL 1 lb of just buds and then if you have extra leaves/ stems add them in, you want roughly 60 grams of oil and 1 lb of buds will give you that usually, try to use good grown cannabis, you dont want poorly lit grown Cannabis as its Cannabinoid levels will be low, the higher the Cannabinoid count the better as your oil will be more “potent” in medicinal “power”. ingest the 60 grams in no more than 2-3 months, ingesting it when ever you can but you must try to stay able to walk around… you dont want to flood your system with too many Cannabinoids, you want an efficient amount binding to the CB receptor locations and releasing CB receptors so that an efficient amount is always binding to cancerous sites, or areas or healing… you want the maximum amount of PCD(Programmed Cell Death) possible at all times to turn off cancer effectively, so you do this by taking the right amount, some argue this is not important but it is, ingest as much as you can without feeling so high you feel drunk or that you cant walk around or that you may pass out AS OFTEN AS YOU CAN without feeling so high you feel drunk or that you cant walk around or that you may pass out. You may need to work or you may need to go to school, so you need to stand up, im not really sure about going to school on this, lol, if you have cancer and your trying to cure it you shouldnt go to school anyways, stay home.. but as long as you can walk around and speak proper language then your Endocannabinoid system is receiving the correct amount of Cannabinoids. So depending on your tolerance level and everyones is different i promise you- the average amount per dose to take is very small, the size of a grain of rice to the size of a penny, all depends on you, start by trying some lol and enjoy your first time. if your feel like you can take more take more and see if you can still walk around after 15 mins, keep taking if you can, if you get incredibly high and pass out or just feel uncomfortable let it ware off completely and take a shade less than before, once you find this perfect amount for you, youve found your regular dose, take this in the morning as soon as you wake up. once you feel it gone, and it usually takes a couple-few hours, take another dose, once again- depending on your tolerance level- you may have to wait until lunch time to take another one, some might be ready to take another dose at say 10am? depends right.. and then keep taking them up until bed time. and at night its ok to take a bigger dose as your going to sleep anyways and most wont set an alarm or wake up for one to take a dose at night, although that would be ideal.. but for the first few days try to lock this routine down, make sure your not taking to much and not too little, as weeks pass sometimes even days, your tolerance level will rise, just like people who smoke cannabis, you’ll be able to ingest more of it at any given time, so start increasing your dose amounts or times per day you administer the doses, remember taking as much as you can as often as you can this is ensuring that there’s always action of shutdown happening in the cells that contain YOUR CANCER. To ingest as much as you can as often as you can, with an alarm at night time even, 60 grams, maybe 50-maybe 70.. until cancer is gone and then finish the remaining oil to ensure cancer does not return, this takes about 1-2-3 months depending on YOU.
So 1 lb makes about 60 grams of high grade potent anti tumor/cancer Cannabis Oil and it takes about 1-2-3 months to ingest it, you do this for serious forms of cancers and serious other disease, this will eradicate the disease. Depending on your cancer or disease, you may need much less oil or you may need more, and it also depends on if your taking the oil correctly, slower healing times or no healing at all will sometimes happen if your not taking as much oil as you can as often as you can.
7 Years Old Medical Cannabis Oil Patient Mykayla On Ricki Lake
“The journey of a thousand miles begins with one step.” —Lao Tzu 🙂 Thank you for stopping by this channel. This is the full episode of the Ricki Lake Show that aired on January 10, 2013. I wanted to express my eternal gratitude to Mr. Rick Simpson himself, Dr. Janet Sweeney and her dedicated husband George with the Phoenix Tears Foundation and Dr. Bob Melamede for not only saving my life, but the lives of so very many out there in the world. More than 11 minutes of my segment was edited out of the Ricki Lake Show cutting out my comments about these are angels on earth. I can’t control the final edit of a television show. I am only a guest. But I feel it’s important to give credit where credit is due. The best thing is that Ricki has invited me to appear as a regular, which gives us an opportunity to do MORE television in the mainstream to share more patient stories. I’m especially proud of Erin & Brandon parents of Mykayla Comstock and of course the bravest little girl in the world Mykayla 🙂 Erin & Brandon presented themselves in such a professional and articulate manner that I was so very proud to be associated with their mission. I am so touched and inspired by them. The Phoenix Tears Project saves lives. I urge you to find out more and support their efforts. I remember being near death with just weeks to hang on, Dr. Janet Sweeney & George took me personally to the doctor and even paid for the doctor when I was completely tapped out financially back in 2009 from being sick for so long. We can never lose sight of these amazing heroes. We have a huge opportunity here as an entire community to get these stories out to the world. If we show the media, that we WANT and NEED this kind of MAIN STREAM programming, This is our time. We are at a tipping point. Let’s make it happen. Can you help me by sharing all of the videos that I have posted here in the comments with your social networks? Can I ask you to add some comments of support on the links that I’ve shared so that we can share our movement with the world? Think of the lives we will both save and enrich. Think of our abilities to collectively influence public opinion to keep changing laws. This is our time. I need your help and I humbly ask you to support me in this mission. Please stay in touch with me through my social networks.On the Ricki Lake Show Official Website:Medical marijuana has long been a taboo subject, but The Ricki Lake Show tackles the subject matter head on with a debate on the most contentious topic in health care. The parents of a 7-year-old leukemia patient and cancer survivor Cheryl Shuman open up to Ricki on the positive effects of using cannabis in their treatments. In a daytime exclusive, Erin and Brandon made national headlines with their controversial decision to administer marijuana to their 7-year-old daughter who is battling an aggressive form of cancer. Medical cannabis advocate Cheryl Shuman has been helping the couple with treatments for their daughter. Cheryl Shuman battled for her own life after ovarian cancer almost took her life, but she turned to medical marijuana and survived the disease.In a television first, Shuman showcases legal cannabis products in the “Medical Controversies” episode. Shuman, known as the “Martha Stewart of Marijuana,” became an advocate and expert in the field for the $47 billion cannabis industry. See Reuters article :http://www.reuters.com/article/2013/01/08/idUSnMKW72163a+1c0+MKW20130108
Mykayla Comstock, a 7-year-old girl with leukemia, uses a gram of medical marijuana daily to combat side effects from her chemotherapy
Mykayla Comstock, a 7-year-old girl with leukemia, is one of Oregon’s youngest medical marijuana users.
Mykayla, who was diagnosed with acute lymphoblastic leukemia last spring, is one of 2,201 cancer patients– 52 of them children — authorized to use cannabis by the state, the Oregonian reports.
The girl, who calls herself “Brave Mykayla,” takes a gram of cannabis oil daily to combat side effects of her chemotherapy, such as nausea, restlessness and loss of appetite, but she says that the pills make her feel “funny.”
Mykayla’s mother, Erin Purchase, credits cannabis with her daughter’s remission, but Jesse Comstock, the girl’s father, who is divorced from Purchase, is concerned that the use of medical marijuana will impair his daughter’s mental development.
Oregon law doesn’t require the monitoring of a child’s medical marijuana use by a pediatrician. Under the state’s 14-year-old medical marijuana law, parents are authorized to decide the dosage, frequency and manner of a child’s marijuana consumption.
Although marijuana is listed as a Schedule II narcotic by the State of Oregon, the federal government classifies it as a Schedule I narcotic, which means a physician cannot prescribe it, according to the Oregon Medical Marijuana Program handbook.
At the time, Cooper Brown was just one of 44 Michigan residents under the age of 18 “with a medical marijuana card,” according to the news outlet. A 7-year-old and two 9-year-olds were also among that group of children.
4 Year Old With Rare Type of Epilepsy Benefits From Medical Marijuana
Topamax. Depakote. Phenobarbital. The list goes on. Before Jayden David turned 5, he had tried a dozen powerful medications to tame a rare form of epilepsy. The side effects were devastating. “If he wasn’t sleeping, he was seizing,” said Jayden’s father, Jason David.
Feeling helpless, David said, he contemplated suicide. He prayed. Then one day he heard about a teenager who was expelled from school for using marijuana to help control seizures.So began the pair’s journey into California’s medical cannabis culture.In the 14 months since, the little boy has been swallowing droppers full of a solution made mostly of cannabidiol, or CBD, the second most prominent of marijuana’s 100 or so cannabinoids. Unlike the dominant THC, cannabidiol is not psychoactive, so the sweet-tasting infusion Jayden takes four times a day doesn’t make him high.Down from 22 prescription pills per day to four, he now eats solid food, responds to his father’s incessant requests for kisses and dances in his Modesto living room to the “Yo Gabba Gabba!” theme song. The frequency and intensity of his seizures have been greatly reduced.But this summer, federal prosecutors moved to close Oakland’s Harborside Health Center — the nation’s largest dispensary and the place David has relied on most for help.The public debate over medical marijuana — which violates federal law but is legal in California, 17 other states and the District of Columbia — for the most part has pitted those who praise its health benefits against those who say it is merely an excuse to get high. Lost in the discussion has been the fact that marijuana has myriad components that affect the body in a number of ways.CBD, for instance, was virtually bred out of U.S. plants decades ago by growers whose customers preferred the mind-altering properties of high-THC varietals. Yet it is experiencing a resurgence, having shown promise as an anti-inflammatory, anticonvulsant, neuroprotectant and cancer-fighting agent.”Nobody is going to a dispensary for this to get high,” said Martin Lee, a Bay Area writer who has reported on cannabidiol for years. “With CBD, it’s clear that it’s just about medicine.” A photo in the kitchen shows a beaming David nuzzled up against his newborn son. But the family’s joy soon clouded. Jayden had his first grand mal at 4 1/2 months. The muscle jerks followed, as did seizures that cause sudden collapse.At 1 1/2, the blue-eyed boy was diagnosed with Dravet syndrome, a form of infant epilepsy described in medical literature as catastrophic — and potentially fatal.
David and Jayden’s mother, whose marriage failed under the stress, consulted top experts, resulting in “more drugs and more ambulance trips,” David said.
By late 2010, Jayden had tried 11 medications. The 12th was stiripentol, hailed as a potential Dravet breakthrough. But after six months, Jayden’s seizures and side effects were worse. David said his son rarely responded to those around him, had difficulty chewing and often screamed in fear.
“I was going crazy,” David said. The onetime jewelry store manager recalled stepping out onto his front lawn in April 2011 to make a phone call: “Mom,” he said. “I’m going to shoot myself in the head. I can’t stand seeing him this way.”
My name is Raphael Mechoulam. Im a professor at Hebrew University. I have been there for many years. Im doing research on the chemistry and biology of natural products, mostly, but also some drugs. There is no drug that has no side effects. I doesnt exist. The same is probably true for cannabis. Now being a chemist, I was particularly interested in the individual constituents of the plant. Surprisingly, the constituents of the cannabis plant were not well known when we started work many years ago, several decades ago. The psychoactive component of cannabis was not known at that time, surprisingly, again. Because morphine had been isolated from opium about 150 years before that, cocaine about 100 years before that, and yet the active component of cannabis had never been isolated in pure form. So my colleague Ani and I went ahead doing that. And we published that compound, reported the isolation of the active compound of cannabis in 1964. Elucidated its structure and a little bit later also synthisized it. So it became available for research. Now scientists like to work with a specified compound. Not just with a mixture because it is very difficult to reproduce the results. And indeed after 1964 there was a lot of work on THC and some of the other constituents which we also isolated and elucidated as structures. And for the next 20 years there was a lot of work done on these compounds and much of the things we know about these compounds, the activity of these compounds, was done at that time. One thing was not known for almost 20 years, and that was the mechanism of THC action, surprisingly so. People thought it maybe some kind of unspecified activity. Acts on the membrane or something. Well it turned out to be a mistake actually. Allan Howlad, a young professor, at that time, a professor of pharmacology at Saint Louis found there is a receptor which was later called Cb1, and then a person in England identified the second receptor known as Cb2. Mostly in the periphery, but then at some point it also pops up in the brain, especially in neurological diseases. So now we are sure of two receptors that are present, and THC acts on them and stimulates them, and causes the activity when needed. Now receptors are not present in the body because there is a plant outside there. They are present in the body in order to be activated by something the body produces when and where needed. So we went ahead looking for the compounds in the brain and periphery that would activate these receptors. And in 1992 and 1995, we reported the most important ones. One of them we called anandamide. Ananda comes from the Sanskrit name supreme joy, we were happy after working so hard identifying the compound. Which has, it turns out, to have a different chemical structure from the compound in the plant. It was rather strange, I would say, because the two compounds do exactly the same. And these compounds, which were identified in the brain and periphery, are derivatives of fatty acids. And these compounds are very important because the receptors are found in large amounts, high concentrations in the brain and peripherary. These compounds are extremely important, they act in a huge number of physiological conditions they interact with other neurotransmitters, they interact in other systems as well. So they are important players in our body. So there has been a huge amount of work on these two compounds. Anandamide, an other one we isolated 2AG, and so we know a lot about the mechanism and how they do and therefore we can also learn a lot about the ability of plant cannabinoids like THC, or synthetic cannabinoids, that can act on this system. Activate it or block it or change the metabolism. So, it is quite promising. Chances are we shall have drugs, we have minor drugs, but I think that we shall have major drugs in the future that act through this particular system.
Original Parts on YouTube with Transcripts in video description:
David Bearman, M.D. Speaks to Medical Marijuana 411 on the Medicinal Benefits of Cannabis
There are a group of researchers around the world, that are very interested in the endocannabinoid system, interested in how that works, how it functions. Elger is one of those people. He and another PHD named Nichol wrote an article that appeared in Scientific America which I believe is entitled The Brains on Marijuana. We have discovered, we meaning scientists not me, at least two endocannabinoids, two different 21 carbon molecules that have receptor sites that can be stimulated by Cannabis. And Cannabis of course, has 66, at least 66 cannabinoids and those are 21 carbon molecules that may have different side chain and every time you have a different side chain you have a different substance. The endocannabinoid system was first characterized by Dr. Raphael Mechoulam who is an Israeli scientist. He isolated THC in 1964. He really is the grand ole man in terms of both research and clinical application of tincture of cannabis. In Israel they use Cannabis for treating PTSD, and has been used elsewhere, in Croatia its used to treat PTSD (Post Traumatic Stress Disorder). He also developed a synthetic molecule, Dextro Cannabinal, which he tested to see if it had neuron sparing effects. There has been a lot of anecdotal evidence that Cannabis is useful in retarding the progress of Multiple Sclerosis and Parkinson’s Disease. What Mechoulam was looking at was whether or not this Dextro Cannabinol would diminish brain damage from strokes or traumatic brain injury. And while the studies he has done so far have shown that it does, it is not at the .05 levels, so those changes might be due to chance. He has discovered or there have been discovered two naturally occurring Cannabinoids in human beings. One is called Anandamide and the other is called 2AG (shorthand for it). Mechoulam has postulated, he has guessed, that there may be as many as four, five or six more Cannabinoids in the human body that we are unaware of. We also know that there are at least two different kinds of receptors. One is called the CB1 receptors, which are located largely in the central nervous system and the other are the CB2 receptors which are located largely in the gut. Now, having those receptors in the gut is interesting because a study done by Dr Jefferey Hergenrather, in which Dr Todd Mikuriya and myself assisted him to a small extent, on Krones patients found that Krones patients who sought recommendations from physicians for the medical use of marijuana, that the cannabis allowed them to decrease their dose of steroids or eliminate their steroids, to decrease other medications specific to Crohns disease, they had less abdominal pain, they had fewer watery stools, less frequency of bowel movements in other words, their quality of life was substantially improved. And what I think happened there is the problems with Krone disease in part are caused by excessively vigorous peristalsis, contractions of the smooth muscle of the GI tract, and the CB2 receptors when they are stimulated by cannabinoids, whether the cannabinoids come from inside the human body manufactured by us or whether they come from a pill made by a pharmaceutical company such as Marinol (Dronabinol) or whether they come from marijuana, you have this retrograde inhibition. It slows down the speed of neurotransmission. The bigger the peristaltic contraction is not as great, it is not as aggressive, as you will. The stool, the digesting food stays in the GI tract longer, the large bowel is their to de-water it so you will have fewer stools, better formed stools, you are going to have less vigorous contractions, so you are not going to decrease the blood supply to the muscles, you are going to have less pain. It is important as we start to look at this that we understand that things don’t work by magic. We have neurotransmitters, we have receptor sites, we are really at the dawn of understanding the neurochemistry regarding the endo cannabinoid system. I think we have really exciting things that we are going to see in the future.
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When access is not fair and equitable… When any patient, caregiver or loved one continues to suffer… When prohibitions are still in place… When pioneering dispensaries are forced to shut down under “Legalization”… When Human Beings can still lock other Human Beings up in jail for a plant… ..all too, while LPs are permitted to use harmful but approved pesticides, sprays and also irradiate nontoxic cannabis for profit…
