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Iodine-Promoted Aromatization of p-Menthane-Type Phytocannabinoids.

J Nat Prod. 2017 Dec 14. doi: 10.1021/acs.jnatprod.7b00946. [Epub ahead of print] Pollastro F1, Caprioglio D1, Marotta P1, Moriello AS2, De Petrocellis L2, Taglialatela-Scafati O3, Appendino G1. Author information Abstract Treatment with iodine cleanly converts various p-menthane-type phytocannabinoids and their carboxylated precursors into cannabinol (CBN, 1a). The reaction is superior to previously reported protocols in […]

Cannabidiol (CBD) as an Adjunctive Therapy in Schizophrenia: A Multicenter Randomized Controlled Trial.

Am J Psychiatry. 2017 Dec 15:appiajp201717030325. doi: 10.1176/appi.ajp.2017.17030325. [Epub ahead of print] McGuire P1, Robson P1, Cubala WJ1, Vasile D1, Morrison PD1, Barron R1, Taylor A1, Wright S1. Author information Abstract OBJECTIVE: Research in both animals and humans indicates that cannabidiol (CBD) has antipsychotic properties. The authors assessed the safety and effectiveness of CBD in […]

Potent anti-inflammatory and pro-resolving effects of anabasum in a human model of self-resolving acute inflammation.

Clin Pharmacol Ther. 2017 Dec 14. doi: 10.1002/cpt.980. [Epub ahead of print] Motwani MP1, Bennett F1, Norris PC2, Maini AA1, George MJ1, Newson J1, Henderson A1, Hobbs AJ3, Tepper M4, White B4, Serhan CN2, MacAllister R1, Gilroy DW1. Author information Abstract Anabasum is a synthetic analogue of Δ8 – tetrahydrocannabinol (THC)-11-oic acid that in pre-clinical […]

Determination of Acid and Neutral Cannabinoids in Extracts of Different Strains of Cannabis sativa Using GC-FID.

Planta Med. 2017 Dec 13. doi: 10.1055/s-0043-124088. [Epub ahead of print] Ibrahim EA1,2, Gul W1,3, Gul SW3, Stamper BJ3,4, Hadad GM2, Abdel Salam RA2, Ibrahim AK5, Ahmed SA5, Chandra S1, Lata H1, Radwan MM1, ElSohly MA1,3,6. Author information Abstract Cannabis (Cannabis sativa L.) is an annual herbaceous plant that belongs to the family Cannabaceae. Trans-Δ9-tetrahydrocannabinol […]

Salivary endocannabinoids and N-acylethanolamines upon mastication of a semisolid food: implications in fat taste, appetite and food liking.

Food Funct. 2017 Dec 13. doi: 10.1039/c7fo01772c. [Epub ahead of print] Mennella I1, Di Monaco R2, Balazy A1, Ferracane R1, Miele NA3, Cavella S2, Vitaglione P1. Author information Abstract This study aimed to evaluate whether salivary endocannabinoid (EC) and N-acylethanolamine (NAE) concentrations upon mastication of a semisolid food were involved in the sensory perception of […]

Increased levels of circulating fatty acids are associated with protective effects against future cardiovascular events in non-diabetics.

J Proteome Res. 2017 Dec 13. doi: 10.1021/acs.jproteome.7b00671. [Epub ahead of print] Kamleh MA, McLeod O, Checa A, Baldassarre D, Veglia F, Gertow K, Humphries SE, Rauramaa R, deFaire U, Smit AJ, Giral P, Kurl S, Mannarino E, Tremoli E, Silveira A, Orvik J, Hamsten A, Wheelock CE. Abstract Cardiovascular disease (CVD) is a major […]

The status of support for cannabis regulation in Uruguay 4 years after reform: Evidence from public opinion surveys.

Drug Alcohol Rev. 2017 Dec 12. doi: 10.1111/dar.12642. [Epub ahead of print] Cruz JM1, Boidi MF2, Queirolo R3. Author information Abstract INTRODUCTION AND AIMS: The objective of this study was to measure the public support for marijuana legalisation in Uruguay, both overall and in its provisions, in nearly 4 years after its implementation. DESIGN AND METHODS: […]

Provider Perspectives on Use of Medical Marijuana in Children With Cancer.

Pediatrics. 2017 Dec 12. pii: e20170559. doi: 10.1542/peds.2017-0559. [Epub ahead of print] Ananth P1, Ma C2,3, Al-Sayegh H2, Kroon L4,5, Klein V4, Wharton C4, Hallez E6, Braun I3,7, Michelson K6,8, Rosenberg AR4,5,9, London W2,3, Wolfe J2,3,7. Author information Abstract BACKGROUND: Although medical marijuana (MM) may have utility in the supportive care of children with serious […]

Cannabinoid type 2 receptors in dopamine neurons inhibits psychomotor behaviors, alters anxiety, depression and alcohol preference.

Sci Rep. 2017 Dec 12;7(1):17410. doi: 10.1038/s41598-017-17796-y. Liu QR1,2, Canseco-Alba A3, Zhang HY4, Tagliaferro P3, Chung M3, Dennis E3, Sanabria B3, Schanz N3, Escosteguy-Neto JC3, Ishiguro H5, Lin Z6, Sgro S3, Leonard CM3, Santos-Junior JG7, Gardner EL4, Egan JM8, Lee JW3, Xi ZX4, Onaivi ES9. Author information Abstract Cannabinoid CB2 receptors (CB2Rs) are expressed in […]

Contribution of CB1Rs in anxiety-related behaviors but not locomotor deficits induced by methamphetamine.

Neurosci Lett. 2017 Dec 11. pii: S0304-3940(17)30994-1. doi: 10.1016/j.neulet.2017.12.021. [Epub ahead of print] Ramshini E1, Sepehri G2, Ahmadi M3, Arjmand S3, Khaksari M2, Shabani M4. Author information Abstract Several lines of evidence have indicated that Methamphetamine (METH) exposure leads to neurodegenerative changes in the dopaminergic neurons and subsequently may predispose users to motor deficit. On […]