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Cannabinoid-induced increase of quantal size and enhanced neuromuscular transmission.

Sci Rep. 2018 Mar 16;8(1):4685. doi: 10.1038/s41598-018-22888-4. Morsch M1,2, Protti DA3, Cheng D4, Braet F4,5, Chung RS6, Reddel SW7, Phillips WD8. Author information Abstract Cannabinoids exert dynamic control over many physiological processes including memory formation, cognition and pain perception. In the central nervous system endocannabinoids mediate negative feedback of quantal transmitter release following postsynaptic depolarization. […]

Marijuana use and mortality following orthopedic surgical procedures.

Subst Abus. 2018 Mar 20:1-20. doi: 10.1080/08897077.2018.1449054. [Epub ahead of print] Moon AS1,2, Smith W2, Mullen S2, Ponce BA2, McGwin G3,4, Shah A2, Naranje SM2. Author information Abstract BACKGROUND: The association between marijuana use and surgical procedures is a matter of increasing societal relevance that has not been well studied in the literature. The primary […]

The Use of Cannabinoids in Colitis: A Systematic Review and Meta-Analysis.

Inflamm Bowel Dis. 2018 Mar 19;24(4):680-697. doi: 10.1093/ibd/izy014. Couch DG1, Maudslay H1, Doleman B1, Lund JN1, O’Sullivan SE1. Author information Abstract BACKGROUND: Clinical trials investigating the use of cannabinoid drugs for the treatment of intestinal inflammation are anticipated secondary to preclinical literature demonstrating efficacy in reducing inflammation. METHODS: We systematically reviewed publications on the benefit […]

Medical cannabis in the treatment of cancer pain and spastic conditions and options of drug delivery in clinical practice.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2018 Mar 19. doi: 10.5507/bp.2018.007. [Epub ahead of print] Landa L1,2, Jurica J1,3, Sliva J4, Pechackova M5, Demlova R1,3. Author information Abstract The use of cannabis for medical purposes has been recently legalised in many countries including the Czech Republic. As a result, there is increased […]

The effect of nabilone on appetite, nutritional status, and quality of life in lung cancer patients: a randomized, double-blind clinical trial.

Support Care Cancer. 2018 Mar 17. doi: 10.1007/s00520-018-4154-9. [Epub ahead of print] Turcott JG1, Del Rocío Guillen Núñez M2, Flores-Estrada D1, Oñate-Ocaña LF3, Zatarain-Barrón ZL1, Barrón F1, Arrieta O4. Author information Abstract BACKGROUND: Over one half of the patients diagnosed with advanced lung cancer experience anorexia. In addition to its high incidence, cancer-induced anorexia promotes […]

Reduced levels of the endocannabinoid arachidonylethanolamide (AEA) in hair in patients with borderline personality disorder – a pilot study.

Stress. 2018 Mar 16:1-4. doi: 10.1080/10253890.2018.1451837. [Epub ahead of print] Wingenfeld K1, Dettenborn L2, Kirschbaum C3, Gao W3, Otte C1, Roepke S1. Author information Abstract Endocannabinoids are involved in depressive and anxious symptoms and might play a role in stress-associated psychiatric disorders. While alterations in the endogenous cannabinoid system have been repeatedly found in patients […]

Cannabinoid Receptors, Mental Pain and Suicidal Behavior: a Systematic Review.

Curr Psychiatry Rep. 2018 Mar 15;20(3):19. doi: 10.1007/s11920-018-0880-4. Colino L1, Herranz-Herrer J1, Gil-Benito E1, Ponte-Lopez T1, Del Sol-Calderon P1, Rodrigo-Yanguas M1, Gil-Ligero M2, Sánchez-López AJ2,3,4, de Leon J5,6,7, Blasco-Fontecilla H8,9,10. Author information Abstract PURPOSE OF REVIEW: The current serotonin-based biological model of suicidal behavior (SB) may be too simplistic. There is emerging evidence that other […]

Maternal administration of cannabidiol promotes an anti-inflammatory effect on the intestinal wall in a gastroschisis rat model.

Braz J Med Biol Res. 2018 Mar 15;51(5):e7132. doi: 10.1590/1414-431X20177132. Callejas GH1, Figueira RL1, Gonçalves FLL1, Volpe FAP1, Zuardi AW2, Crippa JA2, Hallak JE2, Sbragia L1. Author information Abstract Gastroschisis (GS) is an abdominal wall defect that results in histological and morphological changes leading to intestinal motility perturbation and impaired absorption of nutrients. Due to […]

An overview of health and safety in the Colorado cannabis industry.

Am J Ind Med. 2018 Mar 14. doi: 10.1002/ajim.22834. [Epub ahead of print] Walters KM1, Fisher GG1, Tenney L2,3. Author information Abstract BACKGROUND: Understanding worker health and safety in the rapidly growing legal U.S. cannabis industry is important. Although little published research exists, workers may be exposed to biological, chemical, and physical hazards. This study […]

Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome.

Neurology. 2018 Mar 14. pii: 10.1212/WNL.0000000000005254. doi: 10.1212/WNL.0000000000005254. [Epub ahead of print] Devinsky O1, Patel AD2, Thiele EA2, Wong MH2, Appleton R2, Harden CL2, Greenwood S2, Morrison G2, Sommerville K2; GWPCARE1 Part A Study Group. Collaborators (8) Author information Abstract OBJECTIVE: To evaluate the safety and preliminary pharmacokinetics of a pharmaceutical formulation of purified cannabidiol […]