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Perspectives of Cannabinoid type 2 receptor (CB2R) ligands in neurodegenerative disorders: Structure Affinity Relationship (SAfiR) and Structure Activity Relationship (SAR) Studies.

J Med Chem. 2017 Jun 13. doi: 10.1021/acs.jmedchem.7b00155. [Epub ahead of print] Spinelli F, Capparelli E, Abate C, Colabufo NA, Contino M. Abstract Up-regulation of CB2R on activated microglial cells, the first step in neurodegeneration, has been widely demonstrated, and this finding makes the receptor a promising target in the early diagnosis and treatment of […]

Attitudes Toward Medical Cannabis Legalization Among Serbian Medical Students.

Subst Use Misuse. 2017 Jun 12:1-7. doi: 10.1080/10826084.2017.1302959. [Epub ahead of print] Vujcic I1, Pavlovic A1, Dubljanin E2, Maksimovic J1, Nikolic A1, Sipetic-Grujicic S1. Author information Abstract BACKGROUND: Currently, medical cannabis polices are experiencing rapid changes, and an increasing number of nations around the world legalize medical cannabis for certain groups of patients, including those […]

Loose regulation of medical marijuana programs associated with higher rates of adult marijuana use but not cannabis use disorder.

Addiction. 2017 Jun 10. doi: 10.1111/add.13904. [Epub ahead of print] Williams AR1, Santaella-Tenorio J1, Mauro CM1, Levin FR1, Martins SS1. Author information Abstract BACKGROUND AND AIMS: Most U.S. states have passed medical marijuana laws (MMLs), with great variation in program regulation impacting enrollment rates. We aimed to compare changes in rates of marijuana use, heavy […]

Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42/44 MAPK.

Chem Biol Interact. 2017 Jun 7. pii: S0009-2797(16)30434-3. doi: 10.1016/j.cbi.2017.06.005. [Epub ahead of print] Hwang YS1, Kim YJ2, Kim MO3, Kang M3, Oh SW3, Nho YH4, Park SH5, Lee J6. Author information Abstract Melanogenesis plays a critical role in the protection of skin against external stresses such as ultraviolet irradiation and oxidative stressors. This study […]

Adjunctive Management of Itch in Atopic Dermatitis.

Dermatol Clin. 2017 Jul;35(3):373-394. doi: 10.1016/j.det.2017.02.011. Epub 2017 May 6. Elmariah SB1. Author information Abstract Itch, or pruritus, is a hallmark feature of atopic dermatitis (AD). The impact of AD-related pruritus can range from mildly distressing or distracting to completely disabling. Traditionally, management of itch in AD patients has focused on restoring the altered skin […]

Human sperm motility, capacitation and acrosome reaction are impaired by 2-arachidonoylglycerol endocannabinoid.

Histol Histopathol. 2017 Jun 6:11911. doi: 10.14670/HH-11-911. [Epub ahead of print] Francou MM1, Girlea JL2, De Juan A2, Ten J2,3, Bernabeu R3, De Juan J4. Author information Abstract The endocannabinoids are cannabinoids synthesized by mammalian tissues. These compounds are closely related to the regulation of the male reproductive system. However, little is known about the […]

Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake.

Proc Natl Acad Sci U S A. 2017 Jun 5. pii: 201704065. doi: 10.1073/pnas.1704065114. [Epub ahead of print] Chicca A1, Nicolussi S1, Bartholomäus R2, Blunder M3,4, Aparisi Rey A5, Petrucci V1, Reynoso-Moreno IDC1,6, Viveros-Paredes JM6, Dalghi Gens M1, Lutz B5, Schiöth HB3, Soeberdt M7, Abels C7, Charles RP1, Altmann KH2, Gertsch J8. Author information Abstract […]

Development of a new extraction technique and HPLC method for the analysis of non-psychoactive cannabinoids in fibre-type Cannabis sativa L. (hemp).

J Pharm Biomed Anal. 2017 Jun 4;143:228-236. doi: 10.1016/j.jpba.2017.05.049. [Epub ahead of print] Brighenti V1, Pellati F2, Steinbach M3, Maran D1, Benvenuti S1. Author information Abstract The present work was aimed at the development and validation of a new, efficient and reliable technique for the analysis of the main non-psychoactive cannabinoids in fibre-type Cannabis sativa […]

Microorganism design for heterologous biosynthesis of cannabinoids.

FEMS Yeast Res. 2017 Jun 4. doi: 10.1093/femsyr/fox037. [Epub ahead of print] Ângela C1, Hansen EH1, Kayser O2, Carlsen S1, Stehle F2. Author information Abstract During the last decade the use of medical Cannabis has expanded globally and legislation is getting more liberal in many countries, facilitating the research on cannabinoids. The unique interaction of […]

Analysis of Natural Product Regulation of Cannabinoid Receptors in the treatment of Human Disease.

Pharmacol Ther. 2017 Jun 2. pii: S0163-7258(17)30151-1. doi: 10.1016/j.pharmthera.2017.06.003. [Epub ahead of print] Badal S1, Smith KN2, Rajnarayanan R3. Author information Abstract The organized tightly regulated signaling relays engaged by the cannabinoid receptors (CBs) and their ligands, G proteins and other effectors, together constitute the endocannabinoid system (ECS). This system governs many biological functions including […]