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Rationale for cannabis-based interventions in the opioid overdose crisis.

Harm Reduct J. 2017 Aug 18;14(1):58. doi: 10.1186/s12954-017-0183-9. Lucas P1,2,3. Author information Abstract BACKGROUND: North America is currently in the grips of a crisis rooted in the use of licit and illicit opioid-based analgesics. Drug overdose is the leading cause of accidental death in Canada and the US, and the growing toll of opioid-related morbidity […]

Benefits and Harms of Plant-Based Cannabis for Posttraumatic Stress Disorder: A Systematic Review.

Ann Intern Med. 2017 Aug 15. doi: 10.7326/M17-0477. [Epub ahead of print] O’Neil ME1, Nugent SM1, Morasco BJ1, Freeman M1, Low A1, Kondo K1, Zakher B1, Elven C1, Motu’apuaka M1, Paynter R1, Kansagara D1. Author information Abstract BACKGROUND: Cannabis is available from medical dispensaries for treating posttraumatic stress disorder (PTSD) in many states of the […]

Anticonvulsant effect of cannabidiol in the pentylenetetrazole model: Pharmacological mechanisms, electroencephalographic profile, and brain cytokine levels.

Epilepsy Behav. 2017 Aug 15;75:29-35. doi: 10.1016/j.yebeh.2017.07.014. [Epub ahead of print] Vilela LR1, Lima IV2, Kunsch ÉB2, Pinto HPP3, de Miranda AS4, Vieira ÉLM1, de Oliveira ACP2, Moraes MFD3, Teixeira AL5, Moreira FA6. Author information Abstract Cannabidiol (CBD), the main nonpsychotomimetic compound from Cannabis sativa, inhibits experimental seizures in animal models and alleviates certain types […]

The effects of cannabinoid receptors activation and glucocorticoid receptors deactivation in the amygdala and hippocampus on the consolidation of a traumatic event.

Neurobiol Learn Mem. 2017 Aug 14. pii: S1074-7427(17)30128-4. doi: 10.1016/j.nlm.2017.08.004. [Epub ahead of print] Shoshan N1, Akirav I2. Author information Abstract Ample evidence demonstrates that fear learning contributes significantly to many anxiety pathologies including post-traumatic stress disorder (PTSD). The endocannabinoid (eCB) system may offer therapeutic benefits for PTSD and it is a modulator of the […]

Topical Medical Cannabis (TMC): A new treatment for wound pain-Three cases of Pyoderma Gangrenosum.

J Pain Symptom Manage. 2017 Aug 14. pii: S0885-3924(17)30351-2. doi: 10.1016/j.jpainsymman.2017.06.005. [Epub ahead of print] Maida V, Corban J. Abstract Pain associated with integumentary wounds is highly prevalent yet it remains an area of significant unmet need within healthcare. Currently, systemically administered opioids are the mainstay of treatment. However, recent publications are casting opioids in […]

Propagating the Haze? Community and professional perceptions of cannabis cultivation and the impacts of prohibition.

Int J Drug Policy. 2017 Aug 12;48:72-80. doi: 10.1016/j.drugpo.2017.07.015. [Epub ahead of print] Beckett Wilson H1, Taylor S2, Barrett G3, Jamieson J4, Grindrod L5. Author information Abstract BACKGROUND: Recent decades have seen substantial changes in the UK cannabis landscape, including increased domestic production, the ascendancy of stronger strains (namely ‘skunk’) and the drug‘s reclassification under […]

Marijuana and Cannabinoids in ESRD and Earlier Stages of CKD.

Am J Kidney Dis. 2017 Aug 12. pii: S0272-6386(17)30810-7. doi: 10.1053/j.ajkd.2017.06.020. [Epub ahead of print] Rein JL1, Wyatt CM2. Author information Abstract Marijuana is the most commonly used recreational drug in the United States, and legal recreational and medicinal use has gained public acceptance during the last decade. Twenty-nine US states have established medical marijuana […]

Neuroprotective activity of cannabinoid receptor-2 against oxidative stress and apoptosis in rat pups having experimentally-induced congenital hypothyroidism.

Dev Neurobiol. 2017 Aug 11. doi: 10.1002/dneu.22516. [Epub ahead of print] Alcigir ME1, Dogan HO2, Vural SA1, Yilmaz FM3. Author information Abstract In this study, it was aimed to show the cannabinoid receptor-2 (CB2) role, which is a part of neuroprotective endocannabinoidal system, against increasing nitric oxide synthetase (iNOS, eNOS) levels and the apoptotic activity […]

GPR55: A therapeutic target for Parkinson’s disease?

Neuropharmacology. 2017 Aug 11. pii: S0028-3908(17)30384-2. doi: 10.1016/j.neuropharm.2017.08.017. [Epub ahead of print] Celorrio M1, Rojo-Bustamante E1, Fernández-Suárez D2, Sáez E3, Estella-Hermoso de Mendoza A3, Müller CE4, Ramírez MJ5, Oyarzábal J3, Franco R6, Aymerich MS7. Author information Abstract The GPR55 receptor is expressed abundantly in the brain, especially in the striatum, suggesting it might fulfill a […]

The novel cannabinoid receptor GPR55 mediates anxiolytic-like effects in the medial orbital cortex of mice with acute stress.

Mol Brain. 2017 Aug 11;10(1):38. doi: 10.1186/s13041-017-0318-7. Shi QX1, Yang LK1, Shi WL2, Wang L1, Zhou SM1, Guan SY1, Zhao MG1, Yang Q3,4. Author information Abstract The G protein-coupled receptor 55 (GPR55) is a novel cannabinoid receptor, whose exact role in anxiety remains unknown. The present study was conducted to explore the possible mechanisms by […]